導師姓名

范國平

性別

男

職    稱

教授

碩士生導師

科學學位

專業(yè)名稱

人體解剖學與組織胚胎學

博士生導師

科學學位

專業(yè)名稱

生物醫(yī)學工程 

所在院系

醫(yī)學院

聯(lián)系辦法

通訊地址:  上海市四平路1239號同濟大學醫(yī)學院

 郵編: 200092

 手機: 15901901050

Email:

研究方向/

主要特長

主要任職

學習經(jīng)歷:

1994-2001     美國麻省理工學院Whitehead Institute博士后

1990-1995     美國凱斯西儲大學神經(jīng)科學系，獲博士學位

1986-1990     中科院上海細胞所研究生

1982-1986     南京大學生物化學系，獲學士學位

工作經(jīng)歷:

2009-          同濟大學醫(yī)學院干細胞中心        講座教授

2001-          美國加州大學洛杉磯分校醫(yī)學院人類遺傳學系 終身教授

科研業(yè)績

發(fā)表論文 (2000- present的部分代表性文章):

1. 1.    Feng, J., Zhou, Y., Campbell, SL., Le, T., Li, E., Sweatt, JD., Silva, AJ., and Fan, G. (2010). Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons. Nature Neuroscience V13, 423-430.  PMID: 20228804 (highlighted in the News and Views in the same issue of Nature Neuroscience).
2. 2.    Liu B, Tahk S, Yee K., Fan G, Shuai K.  2010. The Ligase PIAS1 Restricts Natural Regulatory T-cell Differentiation by Epigenetic Repression.  Science V.330:521-5.
3. 3.    Liao JL, Yu J, Huang K, Hu J, Diemer T, Ma Z, Dvash T, Yang XJ, Travis GH, Williams DS, Bok D, Fan G. 2010. Molecular Signature of Primary Retinal Pigment Epithelium and Stem-Cell derived RPE cells. Hum Mol Genet. 19(21):4229-38.
4. 4.    Hutnick, LK., Huang,X., Loo, T-C.,  Ma, Z., and Fan G. (2010) Repression of retrotransposal elements in mouse embryonic stem cells is primarily mediated by DNA methylatoin-independent mechanism.  Journal of Biological Chemistry 285(27):21082-91 (Online version published on April 19, 2010) PMID: 20404320
5. 5.     Dvash, T., Lavon, N., and Fan, G. (2010).  Variations of X chromosome inactivation in early passages of human embryonic stem cells.  PLoS One  5(6):e11330.
6. 6.    Zhipeng Fan, Takayoshi Yamaza, Janice S Lee, Jianhua Yu, Songlin Wang, Fan, G., Songtao Shi, Cun-Yu Wang. 2009.  BCOR regulates mesenchymal stem cell function by epigenetic mechanisms: a case study of a rare human genetic disorder OFCD.  Nature Cell Biology 2009 Aug;11(8):1002-9. Epub 2009 Jul 5.PMID: 19578371
7. 7.    Hutnick, L., Golshi, P., Namihira, M., Xue, Z., Matynia, A., Yang, W., Silva, A. Schweizer, F., Fan, G. (2009).  DNA hypomethylation restricted to the murine forebrain induces cortical degeneration and impairs postnatal neuronal maturation.  Human Molecular Genetics 18(15):2875-28885. 
8. 8.    Fouse, S. Shen, Y, Pellegrini, M., Cole, S., Meissner, A., Van Neste, L., and Jaenisch, R., Fan, G. (2008).   Promoter CpG methylation contributes to ES cell-specific gene expression in parallel with the Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation.  Cell Stem Cell 2: 160-169. PMID: 18371437
9. 9.     Shen, Y., Matsuno, Y.,  Fouse, SD., Rao, N., Root, S., Xu, R-H, Pellegrini, M., Riggs, A.D. and Fan, G. (2008)  X-inactivation in female human embryonic stem cells is in a non-random pattern and prone to epigenetic alternations.  PNAS 105(12):4709-14. Epub 2008 Mar 13. [PMCID: PMC2290804].
10. 10.  Wu H, Kim KJ, Mehta K, Paxia S, Sundstrom A, Anantharaman T, Kuraishy AI, Doan T, Ghosh J, Pyle AD, Clark A, Lowry W, Fan G, Baxter T, Mishra B, Sun Y, Teitell MA. (2008) Copy Number Variant Analysis of Human Embryonic Stem Cells.  Stem Cells. 26(6):1484-9. PMID: 18369100
11. 11.  Feng J., Fouse, S., and Fan, G.  (2007).  Epigenetic regulation of neural gene expression and neuronal function.  Pediatric Research. (Review). May;61(5 Pt 2):58R-63R 2007
12. 12.  Golshani, P., Hutnick, L., Schweizer, F., Fan, G. (2007). Conditional Dnmt1 deletion in dorsal forebrain disrupts development of somatosensory barrel cortex and thalamocortical long-term potentiation. Thalamus and Related System  3(3):227-233.29.
13. 13.  Shen, Y., Chow, J., Wang, Z., Fan, G. (2006).  Abnormal CpG island methylation occurs during in vitro differentiation of human embryonic stem cells.  Human Molecular Genetics.  15: 2623-2635. PMID: 16870691  
14. 14.  Fan, G., Martinowich, K., Chin, M., He, F., Fouse, S., Hutnick, D., Hattori, D., Ge, W., Shen, Y., Wu, H., ten Hoeve, T., Shuai,  K.,  and Sun, Y. (2005).  DNA methylation controls the timing of astrogliogenesis through regulation of JAK-STAT signaling.   Development  132: 3345-3356. PMID: 16014513
15. 15.  Martinowich, K., Hatorri, D., Wu, H., Fouse, S., He, F., Hu, Y., Fan, G*., Sun, Y*. (*Corresponding authors) (2003). DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation.  Science 302, 890-893. PMID: 14593184
16. 16.  Sun, Y., Nadal-Vicens, M., Misono, S., Lin, M.Z., Hua, X., Fan, G., Greenberg ME. (2001) Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms.  Cell. 104, 365–376. PMID: 11239394
17. 17.  Rio, M., Fan, G., Fekete, C., Kelly, J., Bates, B., Lechan, RM., Jaenisch, J. (2001)   Conditional deletion of brain-drived neurotrophic factor in the postnatal brain causes hyperactivity and obesity.  Molecular Endocrinology. 15, 1748-1757.